The murine COMP (cartilage oligomeric matrix protein) promoter contains a potent transcriptional repressor region
نویسندگان
چکیده
منابع مشابه
Cartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis
Arthritis is a chronic disease with a significant impact on the population. It damages the cartilage, synovium, and bone of the joints causing pain, impairment, and disability in patients. Current methods for diagnosis of and monitoring the disease are only able to detect clinical manifestations of arthritis late in the process. However, with the recent onset of successful treatments for rheuma...
متن کاملCartilage oligomeric matrix protein (COMP) in murine brachiocephalic and carotid atherosclerotic lesions
OBJECTIVE To investigate the hypothesis that COMP can influence the morphology, stability and size of murine atherosclerotic lesions. METHODS ApoE- and ApoE/COMP-knockout mice were fed a high-fat diet to develop atherosclerotic plaques at lesion sites of three different types; inflammatory and fibrous plaques induced in the carotid artery by low or oscillatory shear stress, respectively, and ...
متن کاملTrinucleotide expansion mutations in the cartilage oligomeric matrix protein (COMP) gene.
Pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) are two human autosomal dominant skeletal dysplasias characterized by variable short stature, joint laxity and early-onset degenerative joint disease. Both disorders can result from mut-ations in the gene for cartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein. About one-third of PSACH cases result...
متن کاملEffect of Cartilage Oligomeric Matrix Protein (comp) on Chondrogenesis in Vitro
Introduction: Cartilage oligomeric matrix protein (COMP) is an N-terminal disulfide-linked, 524 kd homopentameric glycoprotein found primarily surrounding chondrocytes in the cartilage extracellular matrix. COMP gene mutations have been identified in two types of autosomal dominant chondrodysplasias that exhibit osteoarthritic phenotypes; pseudoachondroplasia (PSACH) and multiple epiphyseal dys...
متن کاملAnalysis of cartilage oligomeric matrix protein (COMP) in synovial fibroblasts and synovial fluids.
We investigated the expression of cartilage oligomeric matrix protein (COMP) in normal and rheumatoid arthritis (RA) synovial fibroblasts. In situ hybridization (ISH) was conducted on synovial specimens from five RA patients applying specific probes for COMP or fibroblast collagen type I. ISH was combined with immunohistochemistry, applying antibodies to the macrophage marker CD68. Ribonuclease...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2002
ISSN: 1063-4584
DOI: 10.1053/joca.2002.0532